An engineered photoswitchable mammalian pyruvate kinase
نویسندگان
چکیده
منابع مشابه
An engineered photoswitchable mammalian pyruvate kinase
Changes in allosteric regulation of glycolytic enzymes have been linked to metabolic reprogramming involved in cancer. Remarkably, allosteric mechanisms control enzyme function at significantly shorter time-scales compared to the long-term effects of metabolic reprogramming on cell proliferation. It remains unclear if and how the speed and reversibility afforded by rapid allosteric control of m...
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Construction of a digital computer model based on measured kinetic constants of the pyruvate kinase reaction is described. A model omitting divalent cation activator is shown to behave in agreement with observation, and is then used to clarify the quantitative role of this enzyme in the control of glycolysis. The reaction velocity may increase by a factor of 2 to 4 on going from aerobic to anae...
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Background: The frequency of pyruvate kinase (PK) deficiency, an autosomal recessive defect, is approximately 3 per 10,000 individuals in Shiraz and surrounding areas, and is increased due to high consanguinity marriage frequency. The purpose of this study is to obtain data on the frequency and spectrum of gene mutation of PK in newborns, from Shiraz and surrounding areas. Materials and Methods...
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PARLI, C. JOHN, LINDA C. BURNS, SHARADCHANDRA K. MEGHAL, KEITH KINNEBERG, ROBERT M. OWEAL, AND ROGER E. KOEPPE. Pyruvate metabolism in mammalian liver. Am. J. Physiol. 216(6) : 1525-l 533. 1969.-Labeling patterns were determined in I) liver and carcass protein glutamate of glucocorticoid-treated rats and fed or fasted rats, mice, rabbits, hamsters, and guinea pigs from pyruvate-Z-14C; 2) free l...
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ژورنال
عنوان ژورنال: The FEBS Journal
سال: 2017
ISSN: 1742-464X
DOI: 10.1111/febs.14175